ea0016p446 | Neuroendocrinology | ECE2008
Sievers Caroline
, Samann Philipp
, Dose Tatjana
, Czisch Michael
, Dimopoulou Christina
, Schneider Harald
, Rommler Josefine
, Schopohl Jochen
, Stalla Gunter Karl
Background: In acromegaly, few in vivo data exist on changes of the brain parenchyma as a pathology caused by systemically elevated levels of GH and IGF-1. This is in contrast to neuropsychiatric symptoms such as depression, cognitive impairment, personality changes and pain syndromes that accompany the condition. We aimed at measuring brain tissue volumes and white matter pathology in acromegaly.Methods: Forty-three patients (age 54±14 years...